Approach to the Toxicology Patient


Toxicology covers a wide range of presentations including deliberate self-poisoning, recreational drug misuse and abuse, accidental poisoning, occupational exposure and envenomation. Central to the management of the toxicology patient is risk assessment, as it will anticipate the poisoning severity and help guide treatment.

The toxicokinetics of specific agents is also useful to anticipate the timing of symptom onset as well as whether the agent is amenable to techniques to ameliorate toxicity such as decontamination, enhanced elimination and the possibility of antidote therapy.

Risk Assessment

As mentioned already, a through risk assessment is crucial in the approach to the toxicology patient.

Specifically the:

  • agent or agents
  • dose
  • time of ingestion
  • clinical manifestations since ingestion
  • patient co-morbidities

must be established on history and initial examination.

If there is a deliberate self ingestion, a mental health risk assessment should also be undertaken when appropriate.

Screening Investigations:

  • ECG    to assess QT and QRS
  • Paracetamol in patients unable to give a reliable history


The majority of toxicological treatment involves good supportive care, however in individual poisonings there may be a role for specific antidotes, decontamination or elimination techniques to ameliorate toxicity.

Uncommonly poisonings can be life threatening and requires resuscitation along standard lines incorporating the above techniques – the specifics of which will be discussed in each module separately

  • Resuscitation
  • Decontamination techniques including activated charcoal and washing skin after dermal exposure
  • Enhanced Elimination techniques including urinary alkalinisation, multidose activated charcoal and extracorporeal methods
  • Antidote if available
  • Supportive Measures including observation, antiemetics, rehydration, IDC if retention, nursing techniques to manage delirium, benzodiazepines, thromboprophylaxis, prevention of pressure areas


All poisonings at the Princess Alexandra Hospital are managed by the Toxicology Unit and early liaison with the team is important. Most symptoms of poisonings resolve in hours with good supportive care. These patients are usually suitable for transfer to the Short Stay Unit under the Toxicology Unit until medically appropriate for discharge. Deliberate self poisonings need a mental health assessment performed prior to discharge. If recovery from the poisoning is slow, these patients may require ward admission under the Toxicology Unit. Patients with more severe poisonings requiring mechanical ventilation, inotrope therapy or renal replacement therapy will require ICU admission.


  1. Murray L, Daly F, Little M and Cadogan M. ‘Toxicology Handbook’ 2007; Elsevier, Sydney.