Enhanced elimination aims to reduce the severity and duration of an intoxication. As with decontamination, the decision to proceed with enhanced elimination techniques requires a thorough risk/benefit analysis and shouldn’t interfere with resuscitation or good supportive care. It is only available for ingestions with the toxicokinetics amenable to elimination, in particular the volume of distribution and clearance of the drug in question needs to be considered.
Methods of Enhanced Elimination include:
- Multi Dose Activated Charcoal
- Urinary Alkalinisation
- Extracorporeal Techniques
Multi Dose Activated Charcoal (MDAC)
MDAC enhances elimination through the interruption of enterohepatic recirculation and also through gastrointestinal dialysis. MDAC can be considered for a potentially toxic overdose of a drug with a long half-life but small volume of distribution. Complications include constipation, aspiration and obstruction.
Give 50g stat then 12.5g/h
Substances amenable to MDAC:
Urinary alkalinisation increases the elimination of acidic drugs by increasing the proportion of drug in the ionised state in the renal tubules preventing reabsorption. Complications include hypokalaemia, hypocalcaemia and fluid overload.
Give 1-2 mmol/kg sodium bicarbonate bolus followed by an infusion of 25 – 50mmol/h. Monitor urinary pH q2h, aiming for a pH > 7.5. Measure VBG q2h and replace potassium as necessary
Substances amenable to Urinary Alkalinisation:
Extracorporeal techniques of elimination are invasive and are reserved for life threatening intoxications which will not respond to supportive care or antidote administration alone. Haemodialysis is the most common technique employed and can be provided in most intensive care units. It is suitable for water soluble toxins which are small, not highly protein bound, with a small volume of distribution. Charcoal haemoperfusion is not dependent on drug size, water solubility or protein binding – it is only requires the toxin be adsorbed by charcoal – but technically can prove difficult as the cartridges saturate limiting the duration of efficacy.
Substances amenable to HD/haemofiltration:
- Toxic Alcohols
- Metformin induced lactic acidosis
- EXTRIP www.extrip-workgroup.org provides recommendations for extracorporeal elimination techniques for specific drugs
- WikiTox Enhanced Elimination Techniques http://curriculum.toxicology.wikispaces.net/3.2.3+Enhance+Elimination+Techniques